The fire is thought to have started in the kitchen and destroyed the ground and first floor of the home in Old Trafford, Greater Manchester.
Four fire engines and 18 firefighters were called to the house just after 3 am.
A fire service spokesman said: "The house was engulfed by flames and it quickly became apparent people were trapped inside.
"Firefighters using breathing apparatus found one man with serious burns on the ground floor.
"He was taken to hospital in a critical condition but died later- . Two of the brothers were found dead, one in a front bedroom and one in a rear bedroom.
"This was a very tragic incident.
Written by Sunday Mirror; London
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