The two-story cement block building is occupied by Dr. Thomas Kaminsky, DDS.
In addition, the building included two apartments on the second floor.
Both apartments were thought to be occupied.
Everyone in the building was safely evacuated, fire officials said.
"There was heavy smoke," said New Bethlehem Chief Barry Fox.
"We thought we had it under control and it got into the attic and to the roof."
Fox said the building was a total loss.
Fire crews yesterday were demolishing the remains of the structure.
Fox said the fire was accidental and started in one of the apartments.
The tenant ran downstairs to tell Kaminsky that the apartment was on fire, according to Fox.
There were no details available of what caused the fire.
PennDOT reported that the intersection of Route 66 and Route 28 was closed in New Bethlehem.
Route 66 was closed in both directions from I-80 to Route 28 while firefighters cleared the scene.
The road was expected to reopen by 10 p.m. Monday.
A Distant firefighter was treated at the scene. He refused transportation to a hospital, officials said.
Written by The Leader-Times